Re2O delivers purified human-derived extracellular matrix (ECM) into the dermis to reinforce the structure that supports collagen and elastin. Changes become more noticeable from weeks 2–4.
If your skin feels dehydrated and less firm, we start by looking at the structure that supports it.
Dr. Soyoun Koo Dong-An Joongsim ClinicAccording to manufacturer materials
Numbing cream or sedation
Redness and swelling: 1–3 days
Manufacturer recommendation
Rebuilding the skin's support structure
with extracellular matrix
in a skin booster
Re2O is a premium skin booster made from human-derived extracellular matrix (ECM). Collagen, elastin, proteoglycans, and glycosaminoglycans from the dermis are selectively purified, while living cellular components are removed to minimize the risk of foreign-body and immune reactions.
While Rejuran and JUVÉLOOK stimulate cells to produce collagen, Re2O is the only approach that directly replenishes the ECM, the environment those cells live in. It rebuilds the skin's underlying structure as well as improving hydration.
Makes skin firmer from within. Purified ECM activates fibroblasts to produce new type I and III collagen and elastin.
Gradually softens fine lines and deeper wrinkles. Replenishing the ECM that houses collagen and elastin supports areas where the skin has lost volume.
Refines the appearance of pores and smooths skin texture. A thicker, stronger dermis supports the tissue around enlarged pores from within.
Relieves dehydration and restores a clear, healthy glow. As new ECM forms, hyaluronic acid also increases, helping the skin retain moisture.
Restores natural fullness to hollow cheeks and nasolabial folds. The injected ECM immediately adds dermal thickness, followed by new collagen formation.
Keeps skin firm over time. Fibroblasts release growth factors and new blood vessels form, improving the skin's ability to repair itself.
Re2O results depend on how treatment is planned and performed. We take time with every patient. A doctor handles your consultation and performs your treatment personally.
Dr. Soyoun Koo and Dr. Chang-Hwan Cho attended the 2026 Humedix Re2O Fine launch symposium. Dr. Cho has used a range of collagen stimulators in his practice, from Sculptra and Ellansé to Re2O.
Needle injections of Re2O can be uncomfortable. Your doctor may divide treatment between Re2O and the less painful HILO WAVE to reduce overall discomfort.
We take time with every patient. Your consultation and treatment are handled by a doctor; a patient coordinator only helps with pricing.
My skin feels a little smoother
I tried Re2O because my pores and rough skin texture were bothering me. Having my skin condition and the treatment explained beforehand helped me feel more at ease. Since then, the redness has eased and my skin feels a little smoother, though I'm still waiting to see how my pores change.
My skin looks a little more even
I was most curious about how Re2O would change my skin texture. I wouldn't call it a big change yet, but as the redness settled, my skin looked a little more even. The treatment felt comfortable too. I'll give it more time to see what happens with my pores.
My skin felt hydrated and dewy
After Re2O and the finishing cream, my skin felt hydrated and dewy. The treatment itself was more comfortable than I expected, but I felt it was too early to judge the results just from how my skin looked that day. I'll keep an eye on how it changes.
My skin texture feels a little softer
I was concerned about rough skin and noticeable pores. Since having Re2O, my skin texture feels a little softer. The remaining redness has eased quite a bit too. The changes are still small, so I'm watching how things develop, keeping in mind what I was told before treatment.
How does Re2O rebuild the skin's support structure? The injected ECM goes through four stages as it integrates and encourages regeneration. A doctor experienced in Re2O assesses your skin's thickness and firmness, then determines where and how deeply to inject it.
Purified acellular dermal matrix particles are injected into the deep dermis.
They integrate with the surrounding ECM, activating fibroblasts and increasing growth factor release.
New type I and III collagen, elastin, and hyaluronic acid form.
New blood vessels develop, the dermis thickens, and its structure becomes stronger.
Our approach
Dr. Chang-Hwan Cho has used a range of collagen stimulators in his practice, from Sculptra and Ellansé to Re2O. Because needle injections of Re2O can be uncomfortable, he may divide treatment between Re2O and the less painful HILO WAVE to reduce overall discomfort.
Medical Aesthetic Top Rankers: interview with Dr. Chang-Hwan Cho, March 2026
CheeksCheekbonesNasolabial foldsCheek tissueMouth areaJawlineUnder the eyesCompare injectables and thread lifts side by side. The right choice varies from person to person, so your doctor will help you decide at your consultation.
| Treatment | Results | Duration | Comfort | Recovery |
|---|---|---|---|---|
| Re2O | Gradual improvement | Lasts 6 months or more | Mild discomfort | Usually settled by the next day |
| HILO WAVE | Visible right away | Around 3 months | Mild discomfort | No downtime |
| GOURI | Gradual improvement | Lasts 6 months or more | Mild discomfort | No downtime |
| RADIESSE | Visible right away | Lasts 24 months or more | Mild discomfort | No downtime |
| Sculptra | Gradual improvement | Lasts 24 months or more | Mild discomfort | Usually settled by the next day |
Improvement in pore appearance
Measured 4 weeks after treatment
Improvement in firmness
Measured 4 weeks after treatment
Improvement in skin texture
Measured 4 weeks after treatment
From actors preparing for filming to patients planning a wedding or presentation, many people visit us ahead of an important date. Your doctor plans the timing and combination of treatments around your facial features and schedule.
If your event is tomorrow
We schedule Re2O well ahead of an event to allow time for recovery. If your event is very soon, we adjust the plan to use treatments with no downtime.
If your event is a month away
We work backward from your event date to plan a course of treatment around Re2O. Our broad range of devices lets us choose a combination that suits your face.
Usually settle on their own within 1–3 days.
As your skin recovers, changes in firmness and texture begin to show.
Sessions follow the manufacturer's recommended protocol.
Your doctor handles both your consultation and treatment. A patient coordinator can help with pricing.
Your doctor examines the area you want to treat and discusses the changes you hope to see.
Your doctor assesses skin thickness and firmness to determine injection depth and treatment areas.
Choose topical numbing cream or sedation to reduce discomfort.
Purified ECM is distributed evenly into the deep dermis.
Soothing aftercare helps settle redness before you leave.
Conference lectures and seminars with doctors from around the world.
These two products can complement each other's effects. Some patients also mention receiving them together in their reviews.
Explore HILO WAVE →Some patient reviews recommend this combination.
Explore EXION →Some patient reviews recommend this combination.
Explore EMFACE →Our doctors explain skin concerns relevant to Re2O in clear, practical terms.
Daily sunscreen and consistent moisturizing are the foundations of healthier-looking skin.
The doctors at Dong-An Joongsim Clinic
Depending on their ingredients, skin boosters add hydration, support the skin's structure or stimulate collagen production.
The doctors at Dong-An Joongsim Clinic
Under-eye hollows often combine volume loss with thinning skin. Adding volume alone may not address the whole concern.
The doctors at Dong-An Joongsim ClinicRe2O results depend on how treatment is planned and performed. Check whether a doctor personally consults with you and performs your treatment, whether the clinic uses genuine products and supplies, and whether it can combine treatments to suit your face. We take time with every patient. A doctor handles your consultation and performs your treatment personally.
Conventional skin boosters add hydration or stimulate cells. Re2O directly replenishes the ECM that houses collagen and elastin, which is why the manufacturer describes it as an ECM booster.
They differ in their ingredients and how they work. Rejuran uses polynucleotides (PN) to stimulate cells and support regeneration. Re2O uses ECM purified from human acellular dermal matrix to replenish and reinforce the skin's structure. Your doctor assesses skin thickness and firmness to choose the appropriate product.
As the skin recovers, changes in firmness and texture become more noticeable from weeks 2–4. This is a useful time to start comparing before-and-after changes. The manufacturer's measurements also showed improvements in pores, firmness, and texture at four weeks.
According to manufacturer data, Re2O results last at least six months. An initial course of three sessions, four weeks apart, is recommended. Your doctor then determines the interval for further treatment based on your skin.
Yes. A thicker, stronger dermis supports the tissue around enlarged pores from within. Pore appearance showed the greatest improvement among the outcomes measured by the manufacturer. For thin skin, such as the under-eye area, your doctor adjusts the injection depth and amount.
Needle injections can be uncomfortable, so you can choose topical numbing cream or sedation. At Dong-An Joongsim Clinic, we may also divide treatment between Re2O and the less painful HILO WAVE to reduce overall discomfort.
Mild redness or slight swelling immediately after treatment usually settles within 1–3 days. Any bruising gradually fades. The product contains purified ECM with living cellular components removed to minimize the risk of foreign-body and immune reactions. Avoid vigorous massage, saunas, and scrubs for one week.
The price depends on the areas treated, the amount used, the number of sessions, and any accompanying treatments such as HILO WAVE. Your doctor will explain the cost after assessing your skin during the consultation.
In Re2O reviews from Dong-An Joongsim Clinic patients, some describe looking naturally younger overall after combining it with HILO WAVE. Others say they were pleased with the results of the treatment their doctor recommended.
| Manufacturer | L&C BIODistributed by Humedix |
|---|---|
| Type | Human tissueHuman acellular dermal matrix (hADM), AlloClean™ process |
| Ingredients | 89% collagen · 3% elastin0.4% GAGs · 7.6% other ECM |
| Size | 150mgParticle size: 100 μm or less |
| Certifications | FDA-cleared source material · AATB · MFDS |
We take time with every patient. Your doctor leads the consultation and performs the treatment, with a plan based on your facial features.
